The Top 200 of 2018

Provided by the ClinCalc DrugStats Database

The Top 200 Drugs of 2018

Rank Drug Name Total Prescriptions (2015) Annual Change
1 Lisinopril 112,923,790 0
2 Levothyroxine 112,866,004 0
3 Atorvastatin 93,854,430  2
4 Metformin Hydrochloride 83,901,899  1
5 Simvastatin 74,251,611  1
6 Omeprazole 71,728,530  1
7 Amlodipine Besylate 70,986,227  2
8 Metoprolol 70,473,624  2
9 Acetaminophen; Hydrocodone Bitartrate 51,279,737  1
10 Albuterol 49,747,147  1
11 Hydrochlorothiazide 47,917,544  1
12 Losartan Potassium 46,983,233  2
13 Gabapentin 43,320,666  1
14 Sertraline Hydrochloride 38,877,836  1
15 Furosemide 35,455,536 0
16 Acetaminophen 31,012,793  1
17 Atenolol 30,034,519  1
18 Pravastatin Sodium 29,349,783  4
19 Amoxicillin 28,701,204  6
20 Fluoxetine Hydrochloride 28,311,454  14
21 Citalopram 28,069,030 0
22 Trazodone Hydrochloride 27,564,196  6
23 Alprazolam 27,051,071 0
24 Fluticasone 26,484,229  4
25 Bupropion 26,198,463  4
26 Carvedilol 25,388,562  5
27 Potassium 25,105,958  3
28 Tramadol Hydrochloride 24,904,460  2
29 Pantoprazole Sodium 24,723,892  9
30 Montelukast 24,496,294  3
31 Escitalopram Oxalate 24,068,904  14
32 Prednisone 22,864,052 0
33 Rosuvastatin Calcium 22,722,580  3
34 Ibuprofen 22,691,023  1
35 Meloxicam 22,292,807  5
36 Insulin Glargine 22,223,562  8
37 Hydrochlorothiazide; Lisinopril 22,027,208 0
38 Clonazepam 21,817,867  3
39 Aspirin 21,469,892  7
40 Clopidogrel Bisulfate 21,312,667  4
41 Glipizide 20,833,427  1
42 Warfarin 20,760,410  7
43 Cyclobenzaprine 20,206,825 0
44 Insulin Human 20,074,075  25
45 Tamsulosin Hydrochloride 19,713,737  7
46 Zolpidem Tartrate 19,185,054  7
47 Ethinyl Estradiol; Norgestimate 19,052,886 0
48 Duloxetine 17,890,815  8
49 Ranitidine 17,692,837  1
50 Venlafaxine Hydrochloride 17,109,915  2
51 Fluticasone Propionate; Salmeterol Xinafoate 17,082,573  2
52 Oxycodone 16,887,857  10
53 Azithromycin 16,364,609  37
54 Amphetamine 15,846,731 0
55 Lorazepam 15,698,434  2
56 Allopurinol 14,995,272  7
57 Paroxetine 14,808,496 0
58 Methylphenidate 14,521,828  3
59 Estradiol 14,278,513  5
60 Hydrochlorothiazide; Losartan Potassium 14,262,498  1
61 Ethinyl Estradiol; Norethindrone 14,145,039  1
62 Fenofibrate 13,988,394  11
63 Propranolol Hydrochloride 13,854,897  20
64 Glimepiride 13,601,020  2
65 Ergocalciferol 13,333,620  6
66 Esomeprazole 13,177,033  8
67 Spironolactone 12,848,135  13
68 Loratadine 12,766,655  8
69 Naproxen 12,546,896  10
70 Lamotrigine 12,096,327  2
71 Hydrochlorothiazide; Triamterene 11,974,413  4
72 Cetirizine Hydrochloride 11,836,437  3
73 Sulfamethoxazole; Trimethoprim 11,783,366  39
74 Lovastatin 11,455,915  9
75 Diltiazem Hydrochloride 11,405,865  8
76 Clonidine 10,896,072  4
77 Topiramate 10,752,428  2
78 Amoxicillin; Clavulanate Potassium 10,385,586  35
79 Pregabalin 10,205,189  6
80 Folic Acid 10,060,271  2
81 Alendronate Sodium 10,005,087  9
82 Hydrocodone Bitartrate 9,719,420  350
83 Amitriptyline 9,664,825  6
84 Diclofenac 9,574,332  1
85 Insulin Aspart 9,391,154  4
86 Tiotropium 9,390,081  12
87 Quetiapine Fumarate 9,195,115  17
88 Enalapril Maleate 9,191,299  1
89 Bacitracin; Neomycin; Polymyxin B 8,952,811 0
90 Sitagliptin Phosphate 8,939,975  16
91 Diazepam 8,899,752  5
92 Latanoprost 8,452,983  2
93 Ciprofloxacin 8,422,547  9
94 Budesonide; Formoterol 8,320,958  12
95 Hydroxyzine 8,297,684  2
96 Ethinyl Estradiol; Levonorgestrel 8,166,525  63
97 Docusate 7,920,863  14
98 Valsartan 7,865,273  11
99 Finasteride 7,495,165  5
100 Ondansetron 7,443,855  17
101 Ferrous Sulfate 7,427,636  2
102 Cephalexin 7,136,940  10
103 Ezetimibe 6,985,323  15
104 Buspirone Hydrochloride 6,941,561  9
105 Donepezil Hydrochloride 6,725,752  3
106 Lisdexamfetamine Dimesylate 6,696,494  15
107 Insulin Detemir 6,619,637  38
108 Tizanidine 6,576,783  8
109 Celecoxib 6,573,509  6
110 Amlodipine Besylate; Benazepril Hydrochloride 6,485,663  22
111 Doxycycline 6,471,490  3
112 Cyanocobalamin 6,403,243  12
113 Oxybutynin 6,388,504  6
114 Isosorbide Mononitrate 6,353,254  17
115 Morphine 6,345,800  10
116 Insulin Lispro 6,303,715  22
117 Hydralazine Hydrochloride 6,166,631  8
118 Levetiracetam 6,122,304  12
119 Benazepril Hydrochloride 6,118,658  18
120 Divalproex Sodium 6,112,173  18
121 Cholecalciferol; .Alpha.-Tocopherol 6,102,391  8
122 Ramipril 6,031,523  24
123 Nifedipine 5,903,051  13
124 Drospirenone; Ethinyl Estradiol 5,888,671  31
125 Hydrochlorothiazide; Valsartan 5,839,789  3
126 Pioglitazone Hydrochloride 5,802,593  8
127 Famotidine 5,753,397  4
128 Methylprednisolone 5,718,027  35
129 Clindamycin 5,666,422  42
130 Risperidone 5,575,236  2
131 Rivaroxaban 5,563,073  43
132 Hydroxychloroquine Sulfate 5,523,606  1
133 Aripiprazole 5,410,931  14
134 Mometasone 5,409,887  19
135 Sumatriptan 5,399,563 0
136 Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate 5,372,356  79
137 Lansoprazole 5,282,850  5
138 Baclofen 5,174,424  8
139 Mirtazapine 5,132,323  23
140 Promethazine Hydrochloride 5,120,845  10
141 Nitroglycerin 5,045,449  2
142 Digoxin 5,031,707  15
143 Albuterol Sulfate; Ipratropium Bromide 4,970,382  9
144 Prednisolone 4,835,310  5
145 Hydrocortisone 4,725,930  8
146 Verapamil Hydrochloride 4,695,678  26
147 Ropinirole Hydrochloride 4,672,606  6
148 Carisoprodol 4,609,306  3
149 Glyburide 4,501,271  28
150 Nebivolol Hydrochloride 4,413,472  9
151 Triamcinolone 4,402,204  3
152 Gemfibrozil 4,326,858  4
153 Omega-3-acid Ethyl Esters 4,310,586  13
154 Budesonide 4,265,795  19
155 Brimonidine Tartrate 4,237,804  7
156 Doxazosin Mesylate 4,200,095  9
157 Metformin Hydrochloride; Sitagliptin Phosphate 4,189,472  32
158 Phenytoin 4,171,794  2
159 Solifenacin Succinate 4,163,150  95
160 Calcium 4,145,847  16
161 Levofloxacin 4,132,454  25
162 Canagliflozin 4,107,634  162
163 Irbesartan 4,104,291  47
164 Polyethylene Glycol 3350 4,058,937  41
165 Acyclovir 4,057,239  8
166 Methocarbamol 4,024,077  40
167 Terazosin 3,996,782  18
168 Estrogens, Conjugated 3,961,833  59
169 Meclizine Hydrochloride 3,942,058  5
170 Mesalamine 3,897,422  13
171 Testosterone 3,889,706  37
172 Desogestrel; Ethinyl Estradiol 3,855,278  76
173 Lithium 3,787,925  8
174 Temazepam 3,764,312  30
175 Memantine Hydrochloride 3,740,958  5
176 Oxcarbazepine 3,735,665  16
177 Metronidazole 3,680,542  25
178 Valacyclovir 3,600,104  14
179 Magnesium 3,476,716  5
180 Nitrofurantoin 3,421,494  40
181 Benzonatate 3,419,820  20
182 Liraglutide 3,410,389  13
183 Guanfacine 3,389,253  45
184 Sodium 3,350,146  16
185 Apixaban 3,344,741  123
186 Olmesartan Medoxomil 3,333,072  19
187 Pramipexole Dihydrochloride 3,306,983  21
188 Thyroid 3,306,480  1
189 Adalimumab 3,286,280  56
190 Dicyclomine Hydrochloride 3,279,569  16
191 Anastrozole 3,252,197  6
192 Timolol 3,231,775  30
193 Chlorthalidone 3,213,826  1
194 Lidocaine 3,203,738  19
195 Phentermine 3,181,739  25
196 Amiodarone Hydrochloride 3,132,328  18
197 Atomoxetine Hydrochloride 3,051,717  38
198 Ethinyl Estradiol; Etonogestrel 3,043,443  39
199 Fluconazole 3,023,610  27
200 Clobetasol Propionate 3,005,122  25

Note: The data source (MEPS prescribed medicines file) is released annually by the U.S. Government. This data release represents survey data from two years prior. The ClinCalc DrugStats Database sanitizes and standardizes this data, and is typically released within a few months of the MEPS release. There is an inherent delay in collecting the survey data (eg, in the 2016 calendar year), MEPS releasing the data from patients (August 2018), and the ClinCalc DrugStats release (a few months later, classified as the 2019 drug list). Click here to read more about the process of creating the DrugStats database from the MEPS prescribed medicines file.


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2005-2015. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 18.0. Read more about the ClinCalc DrugStats database.

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Which of these drugs causes acute kidney injury? The Top 250 Drugs by ClinCalc Academy
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Updated Feb 11, 2017
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