Hydrochlorothiazide; Lisinopril

Drug Usage Statistics, United States, 2004 - 2014

Number of Prescriptions Over Time (2004 - 2014)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2004 82 -
2005 64  18
2006 49  15
2007 44  5
2008 44 0
2009 30  14
Year Rank Change
2010 41  11
2011 39  2
2012 35  4
2013 26  9
2014 37  11

Patient Out-Of-Pocket Cost Over Time (2004 - 2014)

"Out-of-pocket" cost refers to the payment made by the patient (either cash price or the copay amount). This value does not include reimbursement from a third party payer (eg, Medicare or private insurance) and does not represent the total drug cost.

Usage Statistics of Related Drugs

Drug Name Total Prescriptions (2014)
Lisinopril 115,508,573
Hydrochlorothiazide 50,428,399
Hydrochlorothiazide; Lisinopril (this drug) 23,095,054
Hydrochlorothiazide; Losartan Potassium 14,028,830
Hydrochlorothiazide; Triamterene 10,970,465
Enalapril Maleate 8,768,774
Ramipril 7,511,223
Benazepril Hydrochloride 7,389,230
Hydrochlorothiazide; Valsartan 6,148,008
Amlodipine Besylate; Benazepril Hydrochloride 5,450,572
Quinapril 3,276,074
Bisoprolol Fumarate; Hydrochlorothiazide 2,885,296
Fosinopril Sodium 1,634,531

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Lisinopril And Hydrochlorothiazide
  • Prinzide
  • Zestoretic
Generic Drug Synonyms and Salts
  • Lisinopril; Hydrochlorothiazide
  • Hydrochlorothiazide; Lisinopril

FDA Approval Information

Established Pharmacologic Class (EPC): Thiazide Diuretic, Angiotensin Converting Enzyme Inhibitor
Initial FDA approval date: 2/16/1989
First FDA applicant: Merck Research Laboratories Div Merck Co Inc
First dosage form: Tablet (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2004-2014. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 17.0. Read more about the ClinCalc DrugStats database.


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Gorillas can't learn drug therapy ... but you can. The Top 250 Drugs by ClinCalc Academy
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Updated Mar 4, 2017
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