Bisoprolol Fumarate; Hydrochlorothiazide

Drug Usage Statistics, United States, 2004 - 2014

Number of Prescriptions Over Time (2004 - 2014)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year Rank Change
2004 137 -
2005 76  61
2006 89  13
2007 88  1
2008 129  41
2009 147  18
Year Rank Change
2010 184  37
2011 79  105
2012 110  31
2013 247  137
2014 211  36

Patient Out-Of-Pocket Cost Over Time (2004 - 2014)

"Out-of-pocket" cost refers to the payment made by the patient (either cash price or the copay amount). This value does not include reimbursement from a third party payer (eg, Medicare or private insurance) and does not represent the total drug cost.

Usage Statistics of Related Drugs

Drug Name Total Prescriptions (2014)
Metoprolol 72,320,918
Hydrochlorothiazide 50,428,399
Atenolol 30,837,680
Carvedilol 24,317,623
Hydrochlorothiazide; Lisinopril 23,095,054
Hydrochlorothiazide; Losartan Potassium 14,028,830
Hydrochlorothiazide; Triamterene 10,970,465
Propranolol Hydrochloride 9,858,070
Hydrochlorothiazide; Valsartan 6,148,008
Nebivolol Hydrochloride 4,961,231
Atenolol; Chlorthalidone 4,181,880
Bisoprolol Fumarate; Hydrochlorothiazide (this drug) 2,885,296
Labetalol 2,774,301
Dorzolamide Hydrochloride; Timolol Maleate 1,600,800
Nadolol 1,494,872

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms
  • Bisoprolol Fumarate And Hydrochlorothiazide
  • Ziac
Generic Drug Synonyms and Salts
  • Hydrochlorothiazide; Bisoprolol Fumarate
  • Bisoprolol Fumarate; Hydrochlorothiazide

FDA Approval Information

Established Pharmacologic Class (EPC): beta-Adrenergic Blocker, Thiazide Diuretic
Initial FDA approval date: 3/26/1993
First FDA applicant: Teva Womens Health Inc
First dosage form: Tablet (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2004-2014. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 17.0. Read more about the ClinCalc DrugStats database.


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Gorillas can't learn drug therapy ... but you can. The Top 250 Drugs by ClinCalc Academy
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Updated Mar 4, 2017
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