ClinCalc DrugStats Database

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The Top 200 Drugs of 2017

Rank Drug Name Total Prescriptions (2014) Annual Change
1 Lisinopril 115,508,573 0
2 Levothyroxine 99,992,248 0
3 Metformin Hydrochloride 86,125,658  1
4 Simvastatin 81,518,801  1
5 Atorvastatin 74,227,208  2
6 Metoprolol 72,320,918  1
7 Omeprazole 71,929,303  1
8 Acetaminophen; Hydrocodone Bitartrate 68,756,036  1
9 Amlodipine Besylate 63,722,510  1
10 Hydrochlorothiazide 50,428,398 0
11 Albuterol 48,189,599 0
12 Gabapentin 39,361,473  2
13 Sertraline Hydrochloride 37,723,879 0
14 Losartan Potassium 37,330,149  6
15 Furosemide 37,104,417  3
16 Azithromycin 31,988,786  1
17 Acetaminophen 31,926,190  2
18 Atenolol 30,837,679  2
19 Insulin Human 30,588,285  18
20 Fluticasone 30,573,156  5
21 Citalopram 29,737,921  3
22 Pravastatin Sodium 29,717,750  7
23 Alprazolam 28,897,888 0
24 Potassium 28,365,609  3
25 Amoxicillin 27,585,663  3
26 Tramadol Hydrochloride 25,809,738  4
27 Montelukast 25,670,394  3
28 Trazodone Hydrochloride 25,521,675  5
29 Bupropion 25,061,016  7
30 Rosuvastatin Calcium 24,760,853  2
31 Carvedilol 24,317,622  7
32 Prednisone 24,212,143  3
33 Ibuprofen 24,062,089  1
34 Fluoxetine Hydrochloride 23,867,188  3
35 Warfarin 23,420,139 0
36 Clopidogrel Bisulfate 23,271,222  9
37 Hydrochlorothiazide; Lisinopril 23,095,053  11
38 Pantoprazole Sodium 22,864,144  7
39 Zolpidem Tartrate 22,399,740  11
40 Meloxicam 21,630,829  10
41 Clonazepam 21,068,437  2
42 Glipizide 20,700,897 0
43 Cyclobenzaprine Hydrochloride 20,610,429 0
44 Insulin Glargine 20,384,788  4
45 Escitalopram Oxalate 19,639,202  4
46 Aspirin 18,251,902 0
47 Ethinyl Estradiol; Norgestimate 17,831,558  7
48 Venlafaxine Hydrochloride 17,385,388  7
49 Fluticasone Propionate; Salmeterol Xinafoate 16,419,775  8
50 Ranitidine 16,215,474  3
51 Fenofibrate 16,184,872  7
52 Tamsulosin Hydrochloride 16,068,805  1
53 Lorazepam 15,947,170  5
54 Amphetamine 15,905,051  18
55 Methylphenidate 15,505,256  9
56 Duloxetine 15,048,113  1
57 Paroxetine 15,020,665  3
58 Esomeprazole 14,963,819  11
59 Naproxen 14,371,092  6
60 Ethinyl Estradiol; Norethindrone 14,183,810  1
61 Hydrochlorothiazide; Losartan Potassium 14,028,830  1
62 Oxycodone 13,888,026  10
63 Allopurinol 13,714,793  15
64 Estradiol 13,220,499  3
65 Lovastatin 12,970,784  9
66 Glimepiride 12,859,036  13
67 Diltiazem Hydrochloride 12,853,214  1
68 Lamotrigine 12,705,157  14
69 Cetirizine Hydrochloride 12,369,433  18
70 Quetiapine Fumarate 11,456,968  15
71 Ergocalciferol 11,170,882  8
72 Clonidine 11,132,422  6
73 Pregabalin 11,069,546  10
74 Tiotropium 11,046,497  4
75 Hydrochlorothiazide; Triamterene 10,970,464 0
76 Loratadine 10,785,216  4
77 Amitriptyline 10,518,139  10
78 Folic Acid 10,404,775  8
79 Topiramate 10,284,071  20
80 Spironolactone 10,225,679  4
81 Insulin Aspart 10,220,895  96
82 Budesonide; Formoterol 10,150,634  7
83 Propranolol Hydrochloride 9,858,069  1
84 Ciprofloxacin 9,312,320  7
85 Diclofenac 9,162,791  12
86 Diazepam 9,134,522  4
87 Valsartan 8,880,976  18
88 Ezetimibe 8,782,265  8
89 Enalapril Maleate 8,768,774  15
90 Alendronate Sodium 8,459,284  19
91 Lisdexamfetamine Dimesylate 8,394,654  10
92 Cephalexin 7,886,065  2
93 Hydroxyzine 7,812,728  11
94 Latanoprost 7,594,870  11
95 Buspirone Hydrochloride 7,560,250  12
96 Desogestrel; Ethinyl Estradiol 7,537,023  24
97 Isosorbide Mononitrate 7,514,558  2
98 Ramipril 7,511,222  17
99 Ferrous Sulfate 7,422,924  21
100 Tizanidine 7,411,430  36
101 Benazepril Hydrochloride 7,389,230  1
102 Divalproex Sodium 7,299,035  17
103 Celecoxib 7,283,822  26
104 Finasteride 7,192,989  10
105 Morphine 7,172,178  4
106 Sitagliptin Phosphate 7,162,884  14
107 Oxybutynin 7,057,593  9
108 Donepezil Hydrochloride 7,003,989  11
109 Estrogens, Conjugated 6,938,375  3
110 Nifedipine 6,887,747  2
111 Docusate 6,797,829  22
112 Sulfamethoxazole; Trimethoprim 6,761,996  10
113 Amoxicillin; Clavulanate Potassium 6,733,526  11
114 Doxycycline 6,712,475  21
115 Mometasone 6,652,178  27
116 Mirtazapine 6,562,967  11
117 Ondansetron 6,548,132  6
118 Pioglitazone Hydrochloride 6,528,320  2
119 Aripiprazole 6,520,070  6
120 Verapamil Hydrochloride 6,473,461  10
121 Glyburide 6,365,008  40
122 Hydrochlorothiazide; Valsartan 6,148,007  7
123 Famotidine 6,091,332  26
124 Cyanocobalamin 6,035,870  39
125 Hydralazine Hydrochloride 5,946,943  7
126 Methocarbamol 5,908,995  24
127 Digoxin 5,860,786  15
128 Risperidone 5,798,068  9
129 Cholecalciferol; .Alpha.-Tocopherol 5,757,506  8
130 Levetiracetam 5,493,521  5
131 Hydroxychloroquine Sulfate 5,473,857  22
132 Amlodipine Besylate; Benazepril Hydrochloride 5,450,572  29
133 Hydrochlorothiazide; Propranolol Hydrochloride 5,401,115  3
134 Testosterone 5,336,442  5
135 Sumatriptan 5,309,154  17
136 Levofloxacin 5,163,786  24
137 Hydrocortisone 5,157,370  15
138 Insulin Lispro 5,016,277  20
139 Prednisolone 5,012,933  30
140 Omega-3-acid Ethyl Esters 5,004,832  25
141 Nebivolol Hydrochloride 4,961,230  31
142 Lansoprazole 4,895,439  25
143 Nitroglycerin 4,871,946  1
144 Temazepam 4,796,392  9
145 Insulin Detemir 4,772,951  17
146 Baclofen 4,764,197  5
147 Doxazosin Mesylate 4,676,441  1
148 Gemfibrozil 4,660,294  11
149 Terazosin 4,505,687  27
150 Promethazine Hydrochloride 4,463,067  16
151 Carisoprodol 4,459,908  23
152 Albuterol Sulfate; Ipratropium Bromide 4,445,835  2
153 Ropinirole Hydrochloride 4,438,220  15
154 Triamcinolone 4,419,530  13
155 Drospirenone; Ethinyl Estradiol 4,415,217  12
156 Phenytoin 4,310,313  25
157 Acyclovir 4,248,866  41
158 Atenolol; Chlorthalidone 4,181,880  18
159 Ethinyl Estradiol; Levonorgestrel 4,170,689  33
160 Oxcarbazepine 4,148,660  52
161 Benzonatate 4,140,925  38
162 Brimonidine Tartrate 4,112,850  44
163 Methylprednisolone 4,109,314  12
164 Meclizine Hydrochloride 4,088,295  17
165 Lithium 4,058,703  4
166 Benztropine Mesylate 4,023,387  71
167 Olmesartan Medoxomil 4,016,252  27
168 Sodium 3,985,912  125
169 Sodium Fluoride 3,977,009  74
170 Phentermine 3,942,606  95
171 Clindamycin 3,914,663  43
172 Fluconazole 3,834,200  31
173 Budesonide 3,808,496  7
174 Rivaroxaban 3,776,704  81
175 Clobetasol Propionate 3,749,794  10
176 Calcium 3,745,361  14
177 Travoprost 3,735,625  64
178 Amiodarone Hydrochloride 3,641,444  10
179 Nortriptyline Hydrochloride 3,621,356  25
180 Memantine Hydrochloride 3,618,231  25
181 Ezetimibe; Simvastatin 3,612,666  35
182 Penicillin V 3,577,360  11
183 Mesalamine 3,530,952  41
184 Magnesium 3,509,192  39
185 Guaifenesin 3,456,761  64
186 Levocetirizine Dihydrochloride 3,451,191  33
187 Thyroid 3,405,708  40
188 Dabigatran Etexilate Mesylate 3,374,192  13
189 Metformin Hydrochloride; Sitagliptin Phosphate 3,361,621  56
190 Beclomethasone 3,283,291  6
191 Quinapril 3,276,073  23
192 Valacyclovir 3,269,988  25
193 Ipratropium 3,256,722  6
194 Chlorthalidone 3,226,084  6
195 Liraglutide 3,212,290  25
196 Dexmethylphenidate Hydrochloride 3,194,849  23
197 Anastrozole 3,146,379  8
198 Diphenhydramine Hydrochloride 3,128,326  77
199 Nystatin 3,127,950  45
200 Desvenlafaxine 3,077,312  17

Want more? Check out the Top 300 Drug List for a more extensive list of the most common outpatient medications in the U.S. market.

What is the ClinCalc DrugStats Database?

The DrugStats database is a sanitized, standardized version of a publicly available database provided by the U.S. Government. This database is updated yearly and includes more than 3 billion outpatient prescription fills per year. This database is a free alternative to the much more expensive IMS Health or QuintilesIMS database, which is more targeted towards pharmaceutical industry.

For more information about DrugStats, including technical analysis of how the database was created, click here to learn more about ClinCalc DrugStats database.


Prescription data source: Medical Expenditure Panel Survey (MEPS) 2004-2014. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 17.0. Read more about the ClinCalc DrugStats database.

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Updated Feb 11, 2017
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