Corticosteroid Conversion Calculator

Calculates equipotent steroid doses

Corticosteroid Regimen

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About This Calculator

The conversion (based on anti-inflammatory potency) is described with a great deal of variability in the literature.1, 2, 3, 4 This calculator uses the following anti-inflammatory potencies to convert between different corticosteroid compounds:

CompoundEquivalent
Dose Question
Anti-inflammatory
Potency Question
Mineralocorticoid
Potency Question
Biological
Half-life
Cortisone25 mg0.80.8
Short
Hydrocortisone20 mg11
Short
Prednisone5 mg40.6
Intermediate
Prednisolone5 mg40.6
Intermediate
Triamcinolone4 mg50
Intermediate
Methylprednisolone4 mg50.25
Intermediate
Betamethasone0.8 mg250
Long
Dexamethasone0.8 mg250
Long
Fludrocortisone-0125
Intermediate

Biological Half-Life

Note that biological half-life is different than plasma half-life. Plasma half-life does not accurately reflect a corticosteroid's duration of action in vivo. The following qualitative biological half-lives are used in the table above:

  • Short: 8-12 hours
  • Intermediate: 12-36 hours
  • Long: 36-72 hours

Fludrocortisone

Fludrocortisone (Florinef) is used for its mineralocorticoid activity (causing increased reabsorption of sodium and loss of potassium/hydrogen). Although fludrocortisone technically possesses a small degree of anti-inflammatory activity (1/10th that of hydrocortisone), this effect is negibile at normal therapeutic doses of fludrocortisone (such as 0.05 to 0.2 mg per day). For this reason, fludrocortisone cannot realistically be converted to another corticosteroid on the basis of anti-inflammatory potency.

References and Additional Reading

  1. Chrousos GP, "Chapter 39. Adrenocorticosteroids & Adrenocortical Antagonists" (Chapter). Katzung BG, Masters SB, Trevor AJ: Basic & Clinical Pharmacology, 11e.
  2. Asare K. Diagnosis and treatment of adrenal insufficiency in the critically ill patient. Pharmacotherapy. 2007;27(11):1512-28. PMID 17963461.
  3. Glucocorticoids. Facts and Comparisons 4.0. Wolters Kluwer Health, Inc. Conshohocken, PA.
  4. Schimmer BP, Funder JW, "Chapter 42. ACTH, Adrenal Steroids, and Pharmacology of the Adrenal Cortex" (Chapter). Brunton LL, Chabner BA, Knollmann BC: Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e.

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Updated Mar 22, 2014
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